Research

My long-standing research interest is in the molecular mechanisms of virus replication. In the laboratory of Dr. Li Wu, I am currently responsible for projects investigating the role of N6-methyladenosine (m6A) modification of HIV-1 and host cell RNAs in regulating virus replication and immune recognition.

Education/Training

Post-doctoral fellowship, Duke University, Durham, NC

Ph.D., Microbiology, The University of Minnesota, Minneapolis, MN

B.S., Microbiology, The University of Iowa, Iowa City, IA

Publications

Phillips, S.L., Mishra T, Khadka S, Bohan D, Espada CE, Maury W, Wu L. Epitranscriptomic N6-Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells. Microbiol Spectr. 2023 Jan 10:e0394322. doi: 10.1128/spectrum.03943-22. Epub ahead of print. PMID: 36625663.

Phillips S. L., Baek A, Kim S, Chen S, Wu L. (2022). Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine. STAR Protoc. 3(3):101616. PMID: 35990737. 

Phillips, S.L., Ramos, P.V., Veeraraghavan, P., and Young, S.M. Jr. 2021. VikAD, a Vika site-specific recombinase-based system for efficient and scalable helper-dependent adenovirus production. Mol. Ther. Methods Clin. Dev. (24): 117-126. PMCID: PMC8718833.

 Lu., W., Li, T.W., Phillips, S.L., and Wu, L. 2021. Reverted HIV-1 mutants in CD4+ T-cells reveal critical residues in the polar region of viral envelope glycoprotein. Microbiol. Spectr. 9(3):e01653-21. PMCID: PMC8693918.

Phillips, S.L., Soderblom, E.J., Bradrick, S.S., and Garcia-Blanco, M.A. 2016. Identification of proteins bound to dengue viral RNA in vivo reveals new host proteins important for virus replication. MBio. 7(1):e01865-15. PMCID: PMC4725007. 

Phillips, S.L., Garcia-Blanco, M.A., and Bradrick, S.S. 2015. Antisense-mediated affinity purification of dengue virus ribonucleoprotein complexes from infected cells. Methods. S1046-2023(15)30047-5. PMCID: PMC4684824.

Phillips, S.L., Cygnar, D., Thomas, A., and Bresnahan, W.A. 2012 Interaction between the human cytomegalovirus tegument proteins UL94 and UL99 is essential for virus replication. J. Virol. 86(18): 9995-10005. PMCID: PMC3446607.  

Phillips, S.L. and Bresnahan, W.A. 2011. The human cytomegalovirus tegument protein UL94 is essential for secondary envelopment. J. Virol. 86(5): 2523-32. PMCID: PMC3302285.

Phillips, S.L. and Bresnahan, W.A. 2011. Identification of binary interactions between human cytomegalovirus virion proteins. J. Virol. 85(1):440-7. PMCID: PMC3014197.

Stacia Phillips  Publications